5-HTP is short for 5-Hydroxytryptophan, which is an amino acid. As a transitional component in tryptophan metabolism, 5-HTP is also a compound which in the metabolic pathway precedes the monoamine neurotransmitter serotonin. As a dietary supplement, 5-HTP is suggested for use as an antidepressant, sleeping aid, but also as an appetite suppressant. Vitamin B6 helps 5-HTP decarboxylate into serotonin, with assistance of a lyase enzyme, namely the aromatic L amino acid decarboxylase. The theory is that 5-HTP, when ingested as a supplement, leads to increased serotonin production. While mainly being used as an appetite suppressant in the body building community, it also improves cognitive abilities, but also endurance and stamina. While there are some concerns in use of 5-HTP and MAO inhibitors in combination, sensitive users report only positive effects, that is why it was included in CMI BIG.

Calcium Phosphate is from the family of minerals containing calcium ions (Ca2+) together with orthophosphates (PO43-), metaphosphates or pyrophosphates (P2O74-) and occasionally hydrogen or hydroxide ions. It is increasingly insoluble at increasing temperatures unlike other chemicals so it precipitates at higher temperatures. Commercially Calcium phosphate is used in production of phosphoric acid and fertilizers. It is also used as nutritional supplement for bone and tooth health. Another practical use of Calcium phosphate is in dental products for demineralization and as diluents in some medicine. It is also used in technologies involving transfection of cells.

Conjugated Linoleic Acid or CLA is a non-essential fatty acid that may be found in cow and sheep meat, and dairy products. It is known to decrease body fat in obese and overweight people. It works by inhibiting the action of the lipoprotein lipase (LPL) enzyme that is responsible for the transfer of fat from the blood stream to the fats cells. It has powerful anti-carcinogenic properties that fight free radical cells from damaging the cells. It also helps control blood sugar levels. It encourages muscle growth and improves the metabolism which accelerates weight loss. It reduces the risk of heart diseases. It is also an antioxidant.

Creatine Alpha-Ketoglutarate , also called creatine AKG is formed by binding together AKG and creatine molecules. Alpha-ketoglutarate is a precursor of glutamine, meaning this supplement provides both glutamine and creatine. The vital benefit is that the intestines absorb AKG more easily, thus preventing diarrhea that most of the bodybuilders experience when they consume creatine monohydrate. Another important benefit of creatine AKG is that AKG crosses readily into muscle tissue without creatine transporters. Creatine and AKG are also utilized in the Krebs cycle -- an aerobic energy-producing pathway -- that is used to replenish the levels of quick energy in muscle cells in between workout sets. Because creatine ensures quick energy for completing more reps, and AKG assists in restoring energy levels between sets, combination of the two is a very effective in keeping energy and strength levels high during workout.

Creatine Ethyl Ester is an organic compound formed by the reaction of alcohols and carboxylic acid. The standard creatine monohydrate is effective in increasing the muscle strength, lean muscle and endurance. Creatine ethyl ester is absorbed by the ability of the cells as the body does not absorb it properly. This is the reason that creatine is taken in large dosages. Creatine ethyl ester is a monohydrate associated with ester. This ester has the significance as it is found in the animals fat tissue. Creatine supplements are blended with protein powder. However, if it is taken for a longer period, the body stops producing it naturally and completely depends on the supplement. The creatine monohydrate shows no reports having side effects. Women also take creatine, but consulting the doctor is recommended. Ethyl ester decreases the amount of retained water as it is made with typical fatty acids that occur naturally. Hence, less creatine is stored as water weight out of the nutrient pocket.

Di-Potassium Phosphate is commonly sprayed on leaves as a fertilizer, and seems also to help control certain fungal diseases on ornamentals. When used in association with another fertilizer, dipotassium phosphate is approved for use in the manufacturing of pesticide products intended to control certain fungal diseases on ornamentals. When label directions are followed, this ingredient is not expected to harm people or the environment.

Folic Acid or Vitamin B9 is essential as it assists the formation of red blood cells in the body and genetic material within every cell. It helps in metabolism of proteins and prevention of anemia and is vital for cell growth and division. Folic acid is an important nutrient for pregnant women to prevent congenital malformation in the fetus. It reduces the risk of brain and spinal cord defects, heart defects, limb defects, urinary tract abnormalities and cleft palate in the fetus. It is highly beneficial if taken prior to and during the first month after conception. In men, folic acid reduces chromosomal defects in the sperm. Spinach, lettuce, peas, beans, sunflower seeds, asparagus, baker’s yeast, fortified cereal products and liver are rich in folic acid.

Glutamine Alpha-Ketogutarate is a combination of nutrients that is assumed to develop lean muscles and at the same time, eliminate body fat. For this reason, athletes and bodybuilders take it as a protein supplement to boost their stamina and improve muscle growth. Glutamine Alpha-Ketogutarate is formed through the binding of a molecule of alpha-ketoglutarate and a pair of Arginine molecules, an amino acid. Glutamine Alpha-Ketogutarate could actually be found in some food including nuts and almonds as well as chocolates and dairy products. The compounds formed from Glutamine Alpha-Ketogutarate, together with leucine, play a major role in muscle metabolism.

L-Aspartic Acid is a proteinogenic alpha amino acid, one of the twenty that are deemed the building blocks of proteins. L-Aspartic Acid is considered non-essential, because the human body can produce it from the organic compound oxaloacetate through a process called transamination. Despite L-Aspartic Acid being classified as non-essential, it is available through dietary sources such as luncheon meats, wild game meat, sausage meat, oat flakes, avocadoes, asparagus and various sprouting seeds. L-Aspartic Acid is also playing a role in the removal of ammonia, but also as a precursor and in the production and synthesis of various biochemical compounds such as arginine, isoleucine, threonine, asparagine, lysine and some nucleotides. In recent years studies have revealed that L-Aspartic Acid seems to raise the body’s resistance to fatigue, thereby boosting endurance.

Mannoheptulose is a heptose, a monosaccharide with 7 carbon atoms. It is found naturally in avocado and can also be synthesized. It functions as a hexokinase inhibitor and prevents glucose phosphorylation. In simpler terms mannoheptulose causes inhibition of insulin secretion in humans, thereby likely inducing "instant diabetes", therefore, it is used in supplements and medicine for people suffering from hypoglycemia(low blood sugar level), which is caused by high insulin levels. Research shows that Mannoheptulose can reduce obesity associated with high insulin levels and there is also a claim about anti-cancer effects of Mannoheptulose.

Melatonin- Main function is to keep the biological clock in humans synchronized but also has a powerful antioxidant quality. Can be important in body building to fight toxins.

Niacin, also called Vitamin B3, exists in two main forms, niacin and niacinamide. The niacin form produces a flushing and itching of the skin when taken at higher dosages and this feeling is only temporary.

Sodium Phosphate is a phosphate supplement. It does not function as a potassium supplement. It aids in the building of strong bones and teeth (with calcium). Also known to Promote energy metabolism and promote growth, maintenance and repair of all body tissues. Sodium Phosphate buffers body fluids for acid-base balance and acidifies urine and reduces possibility of kidney stones.

Vitamin B1, or rather the Vitamin B complex, is a group of vitamins that are all soluble in water and very often coexist in food sources. While every single Vitamin from the B complex group has a name, they are very often referred to by the number added to the Vitamin B group name, like Vitamin B1, which is thiamine, or Vitamin B2, which is riboflavin. Some other compounds have been added to the Vitamin B group at some time, but were later dropped, like adenine, orotic acid or adenosine monophosphate, where later research found that they are either synthesized by the human body or simply no Vitamins. Vitamin B complex supports the metabolism rate, maintains muscle tone and skin, raises functions of the nervous system and the immune system, promotes red blood cells and cell growth and division and much more.

Vitamin B12 is a water soluble vitamin and is one of the 8 B vitamins. It has the chemical formula C63H88CoN14O14P. In the absence of Vitamin B12, the brain and the nervous system will not be able to function properly. It also plays a key role in the formation of blood. Vitamin B12 was discovered from its relation to the ailment pernicious anemia. Plants and animals are not capable of synthesizing VitaminB12; the enzymes required for this purpose are found only in bacteria. Vitamin B12 deficiency in human beings is due to its complex human physiology. It is available singly or in combination with other supplements.

Vitamin B2 is a water-soluble vitamin with no known toxic effects. Riboflavin (Vitamin B2) is necessary in the oxidative process of metabolism. It is also sometimes used to correct certain enzyme deficiencies and improve mental processes.

Vitamin B5 also known as Pantothenic Acid is a natural, inexpensive and safe form of curing acne. It is free from all negative side effects. It is best suited for people with oily skin as it stops the overproduction of oil within our body. It converts the carbohydrates and fats into energy effectively when synthesized with other Vitamin B. Additionally it also helps your body produce red blood cells and metabolizes fats. It plays a significant role in reducing physical and mental stress because it works along with the stress hormone producing adrenal gland. Pantothenic acid is present in all kinds of food and therefore our body gets sufficient amount of it. As it is impossible for our body to become deficient in pantothenic acid, there is no recommended daily amount of it. Eggs, whole grains and milk contain panthothenic acid in large numbers.

Vitamin B6, also known as Pyridoxine, plays an important role in the breakdown of protein, fats and carbohydrates. It helps in the production of antibodies that keeps the immune system strong. It promotes red blood cell (RBC) production. It alleviates the symptoms of premenstrual syndrome or PMS such as headaches, bloating, depression, mood swings, and abdominal pains. Vitamin B6 also prevents the development of kidney stones. It also helps reduce the build-up of homocystein in the vessels that may cause hearth attack. Vitamin B6 is also beneficial in the overall nerve health. It also prevents or decreases the susceptibility to develop carpal tunnel syndrome.