Bioperine or black pepper, which is a common spice, has medicinal properties. It is a tropical plant and India is the largest producer of Piper Nigrum. It possesses anti-bacterial and anti-inflammatory properties. It acts as an antioxidant agent also. Black Pepper contains essential oil, which acts against intestinal flatulence and also stimulates sweating and urination. The essential oil found in Piper Nigrum stimulates stomach cells to produce HCl acid, which helps in digestion. Piper Nigrum also helps in absorption of certain essential micronutrients like coenzyme Q-10, beta-carotene and EGCG. Pepper has its contribution in Ayurvedic medicines also. Pepper seeds are used to prepare sinusitis relieving medicines. It also used for sore throat and dry cough.

Caffeine is extracted from coffee and tea during the process of decaffeination. Caffeine Anhydrous can be produced from dimethyl urea and malonic acid. It stimulates the central nervous system, enhancing the focus, concentration, and alertness, and warding off drowsiness. It is a mild diuretic and can also increase the metabolism. It increases the energy level and reduces fatigue. Aside from increasing mental alertness, it also helps in maximizing weight loss training. It stimulates the metabolism that helps the body to burn fat faster and uses the fat as energy. It also provides physical energy and delays the onset of fatigue.

Synephrine is an adrenergic amines and stimulant with beta-3 receptors. It functions to increase metabolic rate with no effect to heart rate or blood pressure. Synephrine releases adrenaline and noradrenalin in the adipose tissue and the liver. Stimulation of the beta-3 receptor sites to educe the breakdown of fat. It can be added to the group of stimulants, to which belong such supplements as caffeine or ephedrine. Can be used to boost energy, suppress appetite and enhance metabolic rate to burn more calories and increased the energy, but it does not cause so undesired negative cardiovascular effects. Its active ingredients include gelatin, cellulose, and silica and magnesium strearate. Its weight loss abilities are associated with citrus aurantium (synephrine) supplements which give it the stimulant like effects of the alkaloids.

Synthetic Guggulsterones is naturally found in the resin of the guggul plant, it is a plant sterol and the Latin name of the plant is Commiphora mukul. It is believed that in humans, an extract of the guggul plant functions as a farnesoid X receptor inhibitor, theoretically attributing to a diminished synthesis of cholesterol in the liver. It is a very popular nutritional supplement and exists in several synthetic variants which are popular with the body building communities. The most popular application is the one as a weight loss agent, but it has been observed that Synthetic Guggulsterones may also stimulate thyroid function directly. While there is a debate if synthetic or natural guggulsterones are to be preferred, the availability and price of Synthetic Guggulsterones is currently prevailing.

Yohimbe is an alkaloid and the active ingredient of a medicinal herb also known as Pausinystalia yohimbe, formerly named Corynanthe yohimbe. It is noted as a stimulant drug and also as an aphrodisiac. While the medicinal community has conducted numerous studies of yohimbe in conjunction with sexual dysfunctions, in veterinary medicine, yohimbine is employed as the antidode to anesthesia stemming from the drug xylazine in large and small animals. In recent times, yohimbine has been found to instigate fat loss in athletes when taken orally. There are also some formulations available, for a significant price, where yohimbine can be directly applied transdermally to adipose tissue, leading to a local reduction. This application is still in experimentation and should not be used without professional assistance.