Caffeine is the most widely used legal stimulant of the central nervous system and is also used in Thermo Hydroxadrine, with characteristics that have been described as restoration of alertness and removing from drowsiness. Coffee, Tea, many soft drinks and energy drinks as well as nutrition supplements have this ingredient, which is a psychoactive substance, a xanthine alkaloid that can act as a adenosine receptor antagonist, as well as a phosphodiesterase inhibitor. Although regular use of caffeine seems to have nootropic effects, enhancing cognitive abilities, it also is known to provide long term effects on the nervous and cardiovascular system, like in one study it was proven that people with normal to low blood pressure have the possibility of developing a heart disease significantly reduced, as well as the chance of getting the Parkinson’s disease.

Chromium Polynicotinate is a nutritional supplement designed primarily as nutritional support for certain conditions that are typical for sufferers from diabetes mellitus type 2 or age related diabetes. Recent studies have revealed that supplemented chromium can reduce high blood glucose levels, lowering or eliminating nonenzymatic glycation. Further studies reveal that supplementing chromium polynicotinate can help with depression symptoms as well as reduce systolic blood pressure elevation caused by sucrose. People with chromium deficiencies have trouble maintaining stable blood sugar levels. Chromium polynicotinate can assist in regulating the levels of blood sugar, but it also helps with the control of cholesterol, promote the fat removal process and encourage buildup of lean muscles. For these characteristics it is a popular supplement for body building and any muscle building sports enthusiasts.

Cocoa Seed Extract is the extract of the seeds of Theobroma cacao. It is cultivated for its seeds which are present in its pod shaped fruits. The extracts from its seeds have a number of health benefits. They are also used to make chocolate. Studies show that Cocoa extracts contain a high level of flavonoids, specifically epicatechin, which may have beneficial cardiovascular effects on health. The ingestion of flavonol-rich cocoa is associated with acute elevation of circulating nitric oxide, enhanced flow-mediated vasodilatation, and augmented microcirculation. Researchers also found that consumption of Cocoa can reduce risk of cancer and can reduce elevated blood pressure.

Evodiamine is a chemical that is extracted from a particular species of plants that has been shown to reduce overall fat intake.

Garcinia Cambogia- Gambooge, a subtropical version of the Garcinia genus and native to Indonesia, is the local name for garcinia cambogia. It bears a pumpkin like yellow coloured fruit, which extract, together with the rind, is in India a curry condiment. Extracts are also being used in several herbal appetite suppressants, but also in some energy providing products and supplements. In the body building community, besides the weight loss properties of garcinia cambogia, the main component, hydroxycitric acid, or HCA, seems to increase the levels of lipolysis in athletes. HCA may even prove to be more effective in combined use with carnitine and pyruvate. In India, garcinia cambogia was traditionally used to treat edema, constipation, irregular menstruation and against intestinal parasites. Further uses include combating rheumatism and bowel related troubles.

Ginger Root- Ginger is a very popular spice and has been used for culinary purposes for ages. Besides the widespread use in the cuisine of many nations, several traditional medicines, including the Indian and Chinese medicinal practices, have used this Zingiber officinale, as the Latin name goes, for its pain relieving, anti allergenic and anti inflammatory activities. Further uses have been noted for treatment of various ailments of the digestive tract, such as diarrhea and nausea, but also as general stomach settlers. While the use of the ginger root extract has been used in ginger beer and ginger ale beverages, the use as dietary supplement or component in nutritional supplement concoctions is relatively recent. The volatile oils of the ginger root extract have been noted for the antibacterial, analgesic, sedative and antipyretic properties.

Green Tea Extract is very popular with the health conscious community, mainly because of the broad antioxidant features, which are provided by the green tea catechins. It is a very popular nutritional supplement, much more popular than regular green tea, because several green tea extract products have no caffeine. Caffeine is actually contained in larger quantities in green tea than in coffee. Besides the already mentioned catechins, further polyphenols are included in the Asian tea favorite. Green tea furthermore contains carotenoids, ascorbic acid – more commonly known as Vitamin C, Minerals and tocopherols. While there are many proven qualities of green tea extracts, some lesser researched effects have been observed, like reduction of LDL cholesterol, increasing the levels of norepinephrine, weight loss and additional antioxidant qualities.

Guarana, a stimulant derived from the seeds of the Brazilian Guarana plant. Guarana is used to increase alertness and help fight fatigue. It contains caffeine and is usually associated with an "energy crash" several hours after taking a large dose.

Hoodia Gordonii is a succulent from the family Apocynaceae. It is a native plant of South Africa and Namibia. It is also commonly known as Bushman's Hat and Queen of the Namib. In appearance Hoodia gordonii is similar to cactus, but it has large tan colored flowers with strong smell. It has been used in traditional medicine for weight loss since a long time. It is increasingly being used in modern weight loss supplements because research has shown its appetite suppressant effects. Hoodia gordonii is not currently on the list of endangered species, but it is feared to become endangered if its excessive foraging and trade is not controlled.

Hordenine appears naturally in many grains, grassy plants, and in some species of hallucinogenic cactus and it is related to the amino acid tyramine. By stimulating norepinephrine release it helps in achieving weight loss by liberating lipids from adipose tissue. It has a big effect over the central nervous system with its attributes of stimulant. It has active ingredients slowing down food digestion. The effect of this is the ability to go longer without meals because it gives a satiating effect. Also known as N.N. dimethyltyramine, Hordenine is actually an indirectly acting adrenergic substance that’s easily available and also acts as an excitatory hormone that energizes the body as well. Those who want to suppress appetite and increase their energy also benefit from this supplement.

L-Tyrosine is a non-essential amino acid, which is used by the cells in order to synthesize the proteins and appears to help stabilize ones mood during periods of high stress levels.

Octopamine is related to noradrenaline. Octopamine was discovered by Vittorio Erspamer, an Italian scientist in 1948. Octopamine has a significant role in mollusks and is the central nervous system in snail. Octopamine also has a vital role in memory and learning in the fruit fly and honey bee. Octopamine is also useful for the firefly in releasing the light production. Octopamine mobilizes releasing fat in mammals and this has developed into promotion as a slimming aid on the internet. However, there is no apparent evidence about Octopamine facilitating weight loss. Octopamine also significantly increases the blood pressure in combination with stimulants such as weight loss supplements. This is extensively used in energy demanding insects such as spiders, lobsters, crabs and crayfish as their behaviors also include egg-laying, jumping and flying. Among vertebrates, Octopamine substitutes norepinephrine and as well exhibits common side effects. Octopamine is sited in the locust jump such that it modulates the muscle activity allowing the leg muscles to contract effectively.

Pantothenic Acid, also called vitamin B5, which is a water-soluble vitamin required by the human body. Pantothenic acid is needed to form coenzyme-A (CoA), and is vital in the metabolism and synthesis of carbohydrates, proteins, and fats.

Synephrine is an active compound that may be found in the fruit called Citrus aurantium or Zhi Shi in Chinese. Its chemical composition is similar to ephedrine and pseudo-ephedrine that may be found in most over the counter cold or allergy medications, weight loss and energy supplements. Unlike ephedrine, Synephrine is considered to be semi-selective sympathomimetic that targets tissues such as fats instead of the heart. It also helps the metabolism without the negative effects of ephedrine to the nervous system. It also increases the energy level, helps the body burn fat and promotes weight loss. It also aids the body to increase the quickness of caloric expenditure.

Vinpocetine is a compound that is derived from a substance found in the leaves naturally called vincamine. Vinpocetine was established in 1960s. This was available in Japan and Europe with prescription and in Canada and the United States it was available in health food stores as well as online as dietary supplement. Vinpocetine increases the blood circulation and reduces the impairment in the brain. Vinpocetine is given to people suffering with Alzheimer’s disease as a complementary treatment. It enhances the use of oxygen in the brain and protects the brain cell from damage. Thereby it works in enhancing the blood flow towards the brain. Vinpocetine prevents strokes and memory disturbances. Vinpocetine is useful in improving, hearing, eyesight and also in alleviating problems that are connected to menopause. Vinpocetine has effect on the damaged areas in the brain and is also an anti-oxidant. So it shields the brain from aging. The dosage recommended is 5mg tablet twice or thrice daily.

White Willow Bark, more accurately the bark of the deciduous tree, has been known since the ancient times for its medicinal properties. Already the ancient Egyptians, but also Hippocrates, Assyrians and Sumerians have recognized that the powder extracted from the white willow bark is a very potent remedy for fever, but active against pains and aches as well. Salix alba, which is the Latin name for the white willow, contains an active alcoholic beta glycoside that contains D-glucose and is named salicin. Salicin is metabolized in human body to salicylic acid and is very closely related to aspirin. When ingested it has a quinine like bitter taste. Salicylic acid is anti inflammatory and keratolytic, and is commonly used as an additive in weight loss products.

Yerba Matte is potent and refers to a drink that is brewed with dried leaves. It belongs to the holly family that is an evergreen member. This grows in Peru, Argentina, Brazil and Chile. This is as well found in plenty in Paraguay. The Yerba Mate plant is considered as stimulant, aromatic, astringent, bitter, purgative, diuretic and good for inducing sweat and reducing fever. Yerba mate contains many minerals and vitamins. The Yerba Mate leaf has nutrition and antioxidants in plenty and hence North Americans prepare strong tea using this leaf. Yerba mate powder is used to boost immunity and to detoxify blood, restore hair color, combat fatigue, tone nervous system, stimulate mind, control appetite, retard aging, reduce stress and as well eliminate insomnia. The tea is preferred with sugar or some people add mint and few replace the water with milk. The extraction can be done repetitively so that the properties stay beneficial.