Capsaicin is used in several skin preparations and is used to relieve pain. It is available in the market in various forms such as ointments, creams, gels, liquids, lotions, sticks and pads under marketing names such as Capsagel, Zostrix, Arthricare for Women and Icy Hot Arthritis Treatment. A very astonishing fact is that capsaicin happens to be the active part of chili peppers. Though it is an irritant producing burning sensation on any tissue that comes in contact with it, it depletes substance P. Substance P transmits impulses of pan to the brain. It relieves pain due to diseases such as osteoarthritis, diabetes neuropathy and rheumatic arthritis. Capsaicin has not had any drug interactions till date. But this does not means that it can never have any interaction with any other drug. It is always best to confirm with your doctor if you really need to use capsaicin. Also, it is best to use this drug only in specified quantities.

Guarana, a stimulant derived from the seeds of the Brazilian Guarana plant. Guarana is used to increase alertness and help fight fatigue. It contains caffeine and is usually associated with an "energy crash" several hours after taking a large dose.

Kola Nut has a euphoric and stimulating effect on the heart and central nervous system and produces a heightened state of euphoria and well-being.

Yerba Matte is believed to possess cancer-fighting properties and has shown to have a relaxing effect on muscle tissues and a stimulating effect on heart tissues.

Yohimbe contains an alkaline called yohimbine. It releases a hormone that stimulates sexual organs and blood flow in the genitals known as norepinephrine. Yohimbe is known treatment for sexual dysfunctions such as male impotence. It also has aphrodisiac property that improves the libido for both men and women. Yohimbe also helps in weight loss by increasing lypolysis by enhancing the excretion of norephinephrine. It also has antioxidant properties. It may also improve and alleviate exhaustion and feebleness. Yohimbe also helps alleviate the mood by blocking the enzyme called monoamine oxidase that may cause depression. Yohimbe also causes vasodilation that helps lower blood pressure.